ApoLabs

Here you find a (hopefully growing) list of labs involved in apoptosis research from all over the world.

The list includes the principal investigator's name, the lab's location, and a short description of the lab's main research and - of course - a link to the lab's own homepage.

If your lab has not been included, yet, please sign up - for instructions click here!

Australia

Principal Investigator Institution, City, Country Field of Research
Cory, Suzanne The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. Cory's laboratory is currently investigating the biochemistry and interactions of the Bcl-2 family of genes.

Belgium

Principal Investigator Institution, City, Country Field of Research
Vandenabeele, Peter University of Ghent, Department of Molecular Biology, Molecular Signalling and Cell Death Unit, Gent, Belgium The group is studying a variety of cell death (apoptosis and necrosis) related subjects involving caspases, Bcl2 family proteins and IAP family proteins among others .

Brazil

Principal Investigator Institution, City, Country Field of Research
no lab from Brazil yet Institute, City, Brazil what do you do?

Canada

Principal Investigator Institution, City, Country Field of Research
no lab from Canada yet Institute, City, Canada what do you do?

Denmark

Principal Investigator Institution, City, Country Field of Research
Marja Jäättelä Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark The lab is interested in the mechanisms by which cancer cells escape cell death and in alternative death pathways in cancer cells. The molecules of special interest include heat shock proteins, tumor necrosis factor and cathepsins.

England

Principal Investigator Institution, City, Country Field of Research
Franc, Nathalie C. MRC Laboratory for Molecular Cell Biology & Cell Biology Unit, University College London, London, UK. Macrophages and their function in phagocytosis of apoptotic cells during development, using Drosophila melanogaster as a model system.
Watson, Christine Department of Pathology, University of Cambridge, Cambridge, UK. Among others, the group is interested in hormone and growth factor mediated regulation of apoptosis in the mammary gland.

France

Principal Investigator Institution, City, Country Field of Research
Kroemer, Guido Génétique Oncologique, Institut Gustave-Roussy, Villejuif Cedex France The group is working on the dissection of apoptotic mechanisms with emphasis on mitochondrial events involved.
Manon, Stéphen Equipe Mitochondries, Stress et Mort Cellulaire, Université de Bordeaux, Bordeaux cedex, France Yeast as a tool and a model for the study of the molecular mechanisms of apoptosis.
Mignotte, Bernard Université de Versailles/Saint-Quentin, Equipe Apoptose, Versailles, France The group is studying the implication of various factors, such as Bcl-2, Bax, Rb and p53, in the regulation of apoptotic and proliferative processes using mammalian cell systems as well as Drosophila and Yeasts model organisms.

Germany

Principal Investigator Institution, City, Country Field of Research
Drexler, Hannes Max Planck Institute for Physiological and Clinical Research/ Kerckhoff Institut, Dept. Molecular Cell Biology, Bad Nauheim, Germany Areas of interest are the role of the ubiquitin-proteasome system in the regulation of apoptosis, identification and characterization of principles governing the regression of blood vessel, development of tools to induce endothelial specific cell death....
Grimm, Stefan Max Planck Institute for Biochemistry; Martinsried, Germany The lab is applying a genetic screen for the identification and subsequent characterization of novel apoptosis-inducing genes
Janssen, Ottmar Christian-Albrechts-Universität zu Kiel, Institute for Immunology, Kiel, Germany Fields of interest are AICD, Signal Transduction and CD95L reverse signaling...
Krammer, Peter H. Tumor Immunology Program, German Cancer Research Center (DKFZ), Heidelberg, Germany Study of lymphocyte growth under normal and malignant conditions; regulation of cytokine expression; CD95 induced apoptosis.
Pfitzner, Artur University of Hohenheim , Institute for Genetics, Department for General Virology, Stuttgart, Germany Virus induced cell death - model-system: insect cells and rec. Baculoviruses - Expression of BCL-2 genes in plants
Scheller, Carsten Institute for Virology and Immunobiology, University of Wuerzburg, Germany The group is working on the alternative signaling pathways of CD95 and TNF-R1 that lead to necrosis and cytokine expression in lymphocytes and investigates the role of caspases in cellular activation.
Schuetze, Stefan Institute of Immunology at the Universitätsklinikum Kiel, Kiel, Germany Work on TNF receptor, ceramide, and cathepsin-D.

India

Principal Investigator Institution, City, Country Field of Research
Pathak, Chandramani Indian Institute of Advanced Research, Gandhinagar, India Cellular mechanism of Pain. Modulation of Apoptosis for therapy.

Israel

Principal Investigator Institution, City, Country Field of Research
Kimchi, Adi Molecular Genetics Department, Weizmann Institute of Science, Rehovot, Israel. Identification of novel apoptosis-inducing factors by using a functional, antisense cDNA based screening approach.

Italy

Principal Investigator Institution, City, Country Field of Research
no lab from Italy yet Institute, City, Italy what do you do?

Netherlands

Principal Investigator Institution, City, Country Field of Research
Moshage, Han University Hospital Groningen, Department of Gastroenterology and Hepatology, Groningen Netherlands Investigation of the role of apoptosis in inflammatory disorders of liver and gastrointestinal tract. Mechanisms of apoptosis in acute liver failure and liver fibrosis are studied, especially the involvement of NF-kB, PI-3-kinase/Akt survival pathways and the regulation and function of the Bcl-2 family and IAPs .

Japan

Principal Investigator Institution, City, Country Field of Research
no lab from Japan yet Institute, City, Japan what do you do?

Spain

Principal Investigator Institution, City, Country Field of Research
no lab from Spain yet Institute, City, Spain what do you do?

Sweden

Principal Investigator Institution, City, Country Field of Research
no lab from Sweden yet Institute, City, Sweden what do you do?

USA

Principal Investigator Institution, City, Country Field of Research
Alnemri, Emad Kimmel Cancer Center at Jefferson, Philadelphia, PA, USA The lab's research is focused on apoptosis execution and regulation (caspases and the activating/inhibiting machinery).
Bredesen, Dale The Burnham Institute, Apoptosis and Cell Death Research, La Jolla, San Diego, CA, USA Control of cell death in age related cancer and degenerative diseases; focus on the common neurotrophin receptor p75NTR.
Cohen. Michael B. Dept. of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA Investigation of receptor-mediated apoptosis pathways (Fas, TNF, TRAIL) and the role of p53 in prostatic carcinoma cell lines.
Evan, Gerard The University of California at San Francisco, San Francisco, CA, USA The lab studies the molecular basis by which c-Myc triggers apoptosis and how the balance between proliferation and cell death is regulated.
Festoff, Barry W. University of Kansas, School of Medicine, Neurobiology, Kansas City, USA Extracellular and intracellular protease pathways involved in apoptosis in the mammalian central nervous system. Emphasis is on thrombin, protease-activated receptors (PARs), serpin inhibitors and signal transduction pathways involving rho, ERKs, ASK1, JNKs.
Green, Douglas R. La Jolla Institute for Allergy and Immunology, San Diego, CA, USA Immune regulation via Fas-mediated apoptosis; Ceramide in Fas-mediated apoptosis; general mechanisms of apoptosis (mitochondrial events, involvement of oncogenes such as c-myc, Bcl-2, Abl).
Gudkov, Andrei Lerner Research Institute, Department of Molecular Biology, Cleveland, Ohio, USA drug discovery approacher, gene discovery, molecular targets for cancer treatmentTD>
Hengartner, Michael Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA Hengartner's lab uses the nematode Caenorhabditis elegans as model organism to study basic biological problems such as apoptosis.
Knudson, Michael Dept. of Pathology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA The focus of the lab is to study the role of Bcl-2 family members in development and disease.
Kolesnick, Richard D Molecular Pharmacology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA C The lab's work focuses on the role of sphingolipid signaling as a stress response, such as the involvement of ceramide in apoptosis.
Korsmeyer, Stanley Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Characterization of the oncogene bcl-2 and its many family members.
Lazebnik, Yuri Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA The goal of Yuri's lab is to identify and characterize the caspases involved in apoptosis and study their regulation.
Peter, Marcus Ben May Institute for Cancer Research, University of Chicago, IL, USA Mechanisms of death receptor-mediated apoptosis, especially mechanisms of CD95 receptor and caspase-8 mediated apoptosis.
Reed, John The Burnham Institute, La Jolla, San Diego, CA, USA The laboratory studies programmed cell death and its role in cancer and other diseases with focus on Bcl-2.
Rodeck, Ulrich Kimmel Cancer Center, Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, USA Interest in the control of epithelial cell survival by type 1 tyrosine kinases and extracellular matrix as well as the regulation of expression of Bcl-2 family members.
Salvesen, Guy S. The Burnham Institute, Apoptosis and Cell Death Research, La Jolla, San Diego, CA, USA The lab analyzes the basic mechanisms utilized by the caspases to promote cell death pathways.
Wang, Xiaodong Howard Hughes Medical Institute and Department of Biochemistry, The University of Texas, Dallas, TX, USA Biochemical dissection of the apoptotic pathways leading to caspase activation and DNA fragmentation.
Yuan, Junying Dept. of Cell Biology,Harvard Medical School, Boston, MA Dissection of apoptotic pathways with focus on caspases in inflammatory and neuronal degenerative diseases (such as Alzheimer's).
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